Digestive enzymes are those that can break down food materials into utilizable units. They can be taken with food or on an empty stomach to create a systemic effect. Systemic enzymes are taken on an empty stomach as digestion will interfere with their effectiveness.
These enzymes have very specific functions such as the removal of fibrin build up in the body etc. If you use Massyzmes on an empty stomach, they exert a systemic enzyme effect. Therefore, Masszymes can be used as both a digestive and systemic enzyme.